Cardiac glycosides pharmacognosy pdf

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17 Apr 2014 CARDIAC GLYCOSIDES Presented by; M Pharm (Pharmaceutical Chemistry) students Gunturu .Aparna Akshintala. Sree Gayatri Thota. Madhu latha Kamre. Sunil Daram. Se Chemical structure of cardiac glycosides. The R group at the 17-position defines the class of cardiac glycosides, and two classes have been observed in nature, Cardenolides and Bufadienolides according to their chemical structure (Fig. 1). Digitalis Purpurea, Digitalis lanata, Strrophanthius gratus and Strophanthus kombe Cardiac glycosides are a class of organic compounds that increase the output force of the heart and decrease its rate of contractions by acting on the cellular sodium-potassium ATPase pump. Their beneficial medical uses are as treatments for congestive heart failure and cardiac arrhythmias; however, their relative toxicity Pharmacognosy Department,. College of Pharmacy Salman Bin Abdulaziz. University,. Al-Kharj. KSA. Email: amaniawaad@hotmail.com. Pharmacognosy -2. PHG 322 .. Cardiac glycosides. 1-The genins of all cardiac glycosides are steroidal in nature, that act as cardiotonic agents. 2-They are characterized by their highly. 29 Sep 2011 Study of Glycosides according to Pharmacognosy. Pharmacognosy Lecture # 1 (Glycosides) [By, Sir Tanveer Khan] . Classification (a) Cardioactive glycosides: Digitalis, Strophanthus and white squill (b) Anthraquinone glycosides: Cascara, Aloe, Rhubarb, Cochineal and Senna (c) Saponin glycosides: Pharmacognosy and Phytochemistry – Cardiac Glycosides. Page 2. Cardiac Glycosides. ? Therapeutically, this group of compounds may be considered as one of the most important of all natural occurring products. ? Cardioactive glycosides are steroids having the ability to exert specific powerful action on the cardiac On the basis of aglycone structure. • [1] Saponins (soaps). • aglycone = trans-linked steroid. • [2] Cardiac glycosides (poisons). • from squill, digitalis, lily of the valley. • used as crow poisons through history. • aglycone = cis-linked steroid. • [3] Anthracene derivatives (purgatives). • also poisons, cause inconvenience not death. Cardiac glycosides comprise a large family of naturally derived compounds, the core struc? tures of which contain a steroid nucleus with a five-membered lactone ring (cardenolides) or a six-membered lactone ring (bufadienolides) and sugar moieties [1]. A few widely recognized examples of cardiac glycosides are digoxin, 8 Jul 2013 Keywords:Cardiotonic steroids, Anticancer, Digitalis, Cisplatin, Dichloroacetate. How to cite the article:Calderon-Montano J, Burgos-Moron E, Lopez-Lazaro M. The Cardiac Glycosides. Digitoxin, Digoxin and Ouabain Induce a Potent Inhibition of Glycolysis in Lung Cancer Cells. WebmedCentral. CANCER Cardiac glycosides. Flavonoids. Anna Drew. with grateful acknowledgement for inspirational teaching received at. The School of Pharmacy, University of London. Cardiac glycosides. Plant glycosides with specific action on heart. Historical use: to assasinate people, arrow poisons. Historical sources: South American toad