Что такое Мандракс

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Что такое Мандракс

It is a member of the quinazolinone class. The sedative—hypnotic activity of methaqualone was first noted by researchers in the s. In , methaqualone was patented in the US by Wallace and Tiernan. Methaqualone became increasingly popular as a recreational drug and club drug in the late s and s, known variously as 'ludes' or 'sopers' also 'soaps' in the U. The substance is sold both as a free base and as an ammonium salt hydrochloride. Methaqualone is a sedative that increases the activity of the GABA receptors in the brain and nervous system. When GABA activity is increased, blood pressure drops and the breathing and pulse rates slow, leading to a state of deep relaxation. These properties explain why methaqualone was originally mainly prescribed for insomnia. Regular users build up a physical tolerance, requiring larger doses for the same effect. Overdose can lead to nervous system shutdown, coma and death. Methaqualone is not recommended for use while pregnant and is in pregnancy category D. An overdose can cause delirium , convulsions , hypertonia , hyperreflexia , vomiting , kidney failure , coma , and death through cardiac or respiratory arrest. It resembles barbiturate poisoning, but with increased motor difficulties and a lower incidence of cardiac or respiratory depression. In , it was the sixth-bestselling sedative in the US, \\\\\\\\\\\\\\\\\[9\\\\\\\\\\\\\\\\\] where it was legal under the brand name Quaalude. Quaalude in the United States was originally manufactured in by the Fort Washington, Pennsylvania, based pharmaceutical firm William H. The drug name 'Quaalude' combined the words 'quiet interlude' and shared a stylistic reference to another drug marketed by the firm, Maalox. Lemmon also marketed a small quantity under another name, Mequin, so doctors could prescribe the drug without the negative connotations. Methaqualone became increasingly popular as a recreational drug in the late s and s, known variously as 'ludes' or 'sopers' also 'soaps' in the U. It was withdrawn from many developed markets in the early s. In the United States it was withdrawn in and made a Schedule I drug in Mention of its possible use in some types of cancer and AIDS has periodically appeared in the literature since the late s; research does not appear to have reached an advanced stage. Methaqualone was also manufactured in the US under the trade names Sopor and Parest. After the legal manufacture of the drug ended in the United States in , underground laboratories in Mexico continued the illegal manufacture of methaqualone throughout the s, continuing the use of the '' stamp, until their popularity waned in the early s. Drugs purported to be methaqualone are in a significant majority of cases found to be inert, or contain diphenhydramine or benzodiazepines. Methaqualone is one of the most commonly used recreational drugs in South Africa. From Wikipedia, the free encyclopedia. D Evidence of risk. Winter Music First ed. Little, Brown and Company. Archived from the original on February 23, Archived from the original on Retrieved 15 August Image hurt by street use'. Retrieved 16 August Synthesis of substituted 4-quinazolones, I. Glutethimide Methyprylon Pyrithyldione Piperidione. Serotonin antagonists and reuptake inhibitors Etoperidone Nefazodone Trazodone Tricyclic antidepressants Amitriptyline Doxepin Trimipramine , etc. Tetracyclic antidepressants Mianserin Mirtazapine , etc. Typical antipsychotics Chlorpromazine Thioridazine , etc. Atypical antipsychotics Olanzapine Quetiapine Risperidone , etc. Trazodone Tricyclic antidepressants Amitriptyline Doxepin Trimipramine , etc. Agomelatine Melatonin Ramelteon Tasimelteon. Gabapentin Gabapentin enacarbil Mirogabalin Phenibut Pregabalin. GABA A receptor positive modulators. Glutethimide Methyprylon Piperidione Pyrithyldione. Retrieved from ' https: Webarchive template wayback links All articles with dead external links Articles with dead external links from January Articles with permanently dead external links ECHA InfoCard ID from Wikidata Drugboxes which contain changes to watched fields. Views Read Edit View history. In other projects Wikimedia Commons. This page was last edited on 29 August , at By using this site, you agree to the Terms of Use and Privacy Policy. Wikimedia Commons has media related to Methaqualone.

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