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Since then — well, there have been a few more. The definitive heroin movie, for example — Trainspotting? Pulp Fiction? The Basketball Diaries? We may have a good sense of the artistic reputation of, say, booze — from its effects getting drunk to its notable laureates Cheever , but what is the artistic connotation of lean? Here, we attempt to decipher the cultural meaning of a new generation of intoxicants, alongside a few familiar mainstays. May induce: Mental endurance, enhanced concentration, increased focus. Also known as: Beans, study buddies. Status: Prescription. Backstory: A combination of amphetamine and dextroamphetamine, Adderall is a rebranded version of Obetrol, which had its FDA approval as a weight-loss drug withdrawn back in May induce: Relaxation, reduced inhibitions, delusions of literary grandeur. Also known as: Booze, juice, hooch, sauce. Status: Legal. Backstory: This product of fermented grains dates back to at least 7, B. Cultural connotations: Despite its reputation as a party-starter, alcohol works chemically as a depressant, impairing brain functions such as judgment, self-criticism, and inhibition. Notable laureates: Choose one. How about William Faulkner? Dorothy Parker? Christopher Hitchens? May induce: Euphoria, mental alertness, hyperactivity, hypersensitivity. Also known as: Coke, blow, toot, nose candy, Bolivian marching powder. Status: Illegal. Backstory: Peruvians have long chewed coca leaves as part of cultural traditions. Now, cocaine consists of processed coca leaves in the form of a white crystal powder. Cultural connotations: Coke stimulates the release of dopamine, causing a short but intense high that leaves a fierce craving for more. May induce: Mild euphoria, lethargy, a sensation of disassociation with the body. Also known as: Sizzurp, purple drank, dirty Sprite. Status: Codeine is prescription only. Backstory: Lean is a homemade concoction of codeine as contained in cough medicines , Sprite, and Jolly Ranchers, typically sipped out of a double-stacked Styrofoam cup. When Lil Wayne came to national prominence, he brought lean with him. Lean, lean! Lean, lean, lean! May induce: Euphoria, feelings of enhanced empathy. Also known as: E, X, disco biscuits, Scooby snacks. MDMA was first administered in the U. Molly is a resurgent form of ecstasy that commonly comes in powder or crystal form. Cultural connotations: In the s, ecstasy fueled club kids, club kids fueled ecstasy, and the drug became entwined with outlets like the Limelight in New York and Warehouse in Chicago, where house music was born. May induce: Euphoria, relaxation. Also known as: Fent. Backstory: Fentanyl is a synthetic opioid that is similar to morphine but up to times more potent. In , it was linked to more overdoses than any other synthetic opioid. This already dangerously potent and addictive painkiller is often illicitly manufactured in clandestine labs and sold as knockoff Xanax or other prescription pills. Backstory: Opium cultivation from poppies dates back to ancient civilizations. Morphine was derived from opium by , and heroin was synthesized from morphine by an English chemist in And the reasons? There are no reasons. Also known as: Acid. Jimi Hendrix was rumored to put a tab on the inside of his bandanna during concerts and sweat it into his system. The sketches above are from an experiment believed to have been conducted circa by the psychiatrist Oscar Janiger. In the experiment, an artist was given two 50 microgram doses of LSD, separated by an hour, and asked to draw several sketches of the doctor who administered the drug over the course of eight hours. Notable laureates: That would have to be Hunter S. May induce: Minor euphoria, heightened sensory perception, increased appetite. Status: Depends where you live. Backstory: Cultivated for centuries across various civilizations. For example: The guy who gets super-high and goes to his last-ever house party Seth Rogen in This Is the End ; the guy who gets super-high while discussing a possible shmashmortion Seth Rogen in Knocked Up ; the bored process server who happens to witness a murder Seth Rogen in Pineapple Express ; or the alien on the run from the government Seth Rogen in Paul. It is perhaps too soon to gauge how the recent legalization of recreational weed in several states, most recently Vermont, will affect the cultural cachet of marijuana, or the career of Seth Rogen. May induce: Euphoria. Also known as: Oxy, hillbilly heroin. Backstory: The synthetic opioid oxycodone was first derived from an opium alkaloid in In , OxyContin, a pharmaceutical derivative, was hailed as a medical breakthrough for its potential as a long-lasting painkiller; it turned into one of the most widely used recreational opioids in America, fueling the current epidemic. May induce: Euphoria, numbness. Also known as: Percs, blue dynamite. Backstory: Percocet is the brand name for a combination of Oxycodone and acetaminophen. Cultural connotations: Percocet has become a favorite reference in rap music, in part because its reputation as a painkiller evokes a DGAF attitude: Pop a Perc, drink some alcohol, get happy, black out. May induce: Deep relaxation. Also known as: Ludes, lemons. Status: Prescription; no longer manufactured in the United States. It was originally prescribed in the U. Cultural connotations: In his memoir, Keith Richards tells of a speedboat he bought in while living on the French Riviera and recording Exile on Main St. He named the boat Mandrax, which was the brand name for Quaaludes in England. Frank Zappa and David Bowie were also avowed fans. May induce: Mild euphoria. Also known as: Vikes, fluff, scratch. Backstory: Another prescription opioid, Vicodin is a mixture of hydrocodone and acetaminophen and is less potent than Percocet. Vicodin is also a central theme in the medical drama House, where the lead character, the cranky genius Dr. May induce: Reduced anxiety, cognitive impairment. Also known as: Xannies, Xan, benzos. Status: Prescription only. Backstory: Xanax is the trade name for alprazolam, a benzodiazepine anxiolytic commonly prescribed as a tranquilizer for anxiety and panic disorders. Cultural connotations: Much like the connection between heroin and grunge rock, Xanax rose to prominence alongside the subgenre of emo-meets-hip-hop called SoundCloud rap, named for the online platform favored by its most prominent artists. Lil Xan has since announced plans to change his name. Already a subscriber? Log in or link your magazine subscription. Account Profile. Sign Out. An updated guide to the culture of intoxicants. Tags: vulture homepage lede drugs pop culture movies music books vulture guides new york magazine More. Most Viewed Stories.

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