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Benzo fury википедия

It is similar in structure to MDA , but differs in that the 3,4- methylenedioxyphenyl ring system has been replaced with a benzofuran ring. It may appear as a tan grainy powder. While the drug never became particularly popular, it briefly entered the rave and underground clubbing scene in the UK before its sale and import were banned. It falls under the category of research chemicals , sometimes called 'legal highs. The potent agonism of the 5-HT 2B receptor makes it likely that 6-APB would be cardiotoxic with chronic or long-term use, as seen with other 5-HT 2B receptor agonists such as the withdrawn serotonergic anorectic fenfluramine. The pharmacokinetics of 6-APB have not been studied, however, some information can be extracted from user reports. These suggest a slow onset of 40— minutes. The drugs peak effects last 7 hours, followed by a comedown phase of approximately 2 hours, and after effects for up to 24 hours. Although limited literature is available, there is some data on metabolism of 6-APB in rats. Its Phase I metabolism involves hydroxylation of the furan ring, then cleavage of the ring, followed by a reduction of the unsaturated aldehyde from the previous step. The resulting aldehyde may then take two paths. It is either oxidized to a carboxylic acid or reduced to an alcohol , and then hydroxylated. Phase II metabolism consists of glucuronidation. The most prevalent metabolites in rats were 3-carboxymethylhydroxyamphetamine and 4-carboxymethylhydroxyamphetamine. Acute psychosis has been associated with recreational use of 6-APB in combination with the synthetic cannabinoid JWH Marquis , Liebermann , Mecke , and Froehde reagents. Exposing compounds to the reagents gives a colour change which is indicative of the compound under test. A batch seized by the DEA contained a 2: The synthesis by Briner et al. The isomers were separated by silica gel column chromatography , then converted to their respective propanone derivatives, and then reductively aminated to give 6-APB and 4-APB, both of which were converted to their HCl ion pairs for further examination. Certain countries contain a 'substantially similar' catch-all clause in their drug law, such as New Zealand and Australia. From Wikipedia, the free encyclopedia. European Journal of Pharmacology. British Journal of Pharmacology. Drug and Alcohol Dependence. Journal of Medical Toxicology. Diphenidine Ephenidine Fluorolintane Methoxphenidine. Dextrallorphan Dextromethorphan Dextrorphan Racemethorphan Racemorphan. Apomorphine Aporphine Bromocriptine Cabergoline Lisuride Memantine Nuciferine Pergolide Phenethylamine Piribedil Pramipexole Ropinirole Rotigotine Salvinorin A Also indirect D 2 agonists, such as dopamine reuptake inhibitors cocaine , methylphenidate , releasing agents amphetamine , methamphetamine , and precursors levodopa. Glaucine Isoaminile Noscapine Pukateine. Retrieved from ' https: Views Read Edit View history. In other projects Wikimedia Commons. This page was last edited on 11 September , at By using this site, you agree to the Terms of Use and Privacy Policy.

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