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Ecstasy as a Remedy for PTSD? You Probably Have Some Questions.

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The drug known by the street names Ecstasy or Molly could be a promising treatment for post-traumatic stress disorder, according to a new study. Research published Tuesday in the British journal The Lancet Psychiatry found that after two sessions of psychotherapy with the party drug, officially known as MDMA, a majority of 26 combat veterans and first responders with chronic PTSD who had not been helped by traditional methods saw dramatic decreases in symptoms. The improvements were so dramatic that 68 percent of the patients no longer met the clinical criteria for PTSD. The results, which mirror those of similar, small-scale studies of the illegal drug in recent years, come as MDMA is about to enter larger, Phase 3 trials this summer. If large-scale trials can replicate safety and efficacy results, the drug could be approved for legal use by It was like a clean sweep. But the possible legalization of a widely abused party drug raises a lot of questions. If approved by the F. First, a patient goes through three sessions of psychotherapy. In the fourth session, the patient takes a pill. After taking the drug, the patient lies on a futon amid candles and fresh flowers, listening to music. That session lasts eight hours. Michael Mithoefer, one of the principal researchers. The drug floods the brain with hormones and neurotransmitters that evoke feelings of trust and well-being, users report. Researchers say this allows patients to re-examine traumatic memories. In follow-up psychotherapy, patients process emotions and insights brought up during the MDMA session. The current protocol calls for patients to take MDMA two or three times, each a month apart, interspersed with psychotherapy. Mithoefer said. McCourry came home from war unable to escape scenes of an explosion that nearly killed him, and haunted by the memory of two young girls he accidentally killed in a fire fight. He struggled to sleep. He drank to forget. Rage eroded most of his relationships. A handful of medications meant to help left him feeling like a zombie, and he gave them up. He was contemplating suicide when he tried MDMA. I relived the parts of me I had lost. I realized I had viewed myself as a monster, and I was able to start to have some compassion for myself. It was a turning point, and for the next year I continued to get better. Large-scale trials, which will include up to participants at 14 sites, may not be able to replicate the success of previous trials, which were limited to a few dozen patients. But so far, results are encouraging. Nearly all patients saw clinically significant reductions in symptoms, and a majority saw such drastic reductions that they no longer met the criteria for a PTSD diagnosis. Side effects, including anxiety, headache, fatigue, muscle tension and insomnia, were generally minor and limited to the days following the MDMA sessions. Other researchers, intrigued by the results, are starting their own studies of MDMA therapy, including the Department of Veterans Affairs. Not really, said Dr. Only about one in three combat veterans with PTSD are effectively treated, he said. Psychotherapy also has limitations. Though many patients find it helpful, others find it too traumatizing or ineffective and quit therapy. In some studies, dropout rates were as high as 40 percent. Not big pharma. The research is organized by a small nonprofit called the Multidisciplinary Association for Psychedelic Studies, or M. And they have come from an odd array of sources. David Bronner, the vegan C. People already are. While many are likely doing it purely for recreation, word of the therapeutic uses has spread, and combat veterans are trying it illegally at home. But street Ecstasy is dangerous. Doses of the street drug can be an unknown mix of other stimulants and hallucinogens, and an overdose can be fatal. High frequency use of MDMA can also damage the brain. MDMA was originally patented by pharmaceutical giant Merck in , but it was never marketed and the patent lapsed. The F. That would give M. After that, other companies could make it. Yes and no. MDMA is an illegal drug and has never been approved for any use by the F. But for about a decade before it was outlawed in , it was used as an aid in psychotherapy, especially on the West Coast. At the time, academics were beginning to argue that it and other psychedelic drugs could be a useful ally in psychotherapy. The idea failed to gain traction then, but now a number of prestigious researchers are studying the potential therapeutic uses of LSD, psilocybin and MDMA. You Probably Have Some Questions. How might MDMA therapy work? No one goes home with a bottle of Ecstasy. Seems risky. Who is behind these studies? Where does the money come from? Does this mean people can just self medicate with MDMA? Who cashes in if MDMA becomes legal? Is MDMA therapy new? Home Page World U.