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Acetylfentanyl acetyl fentanyl is an opioid analgesic drug that is an analog of fentanyl. Acetylfentanyl was discovered at the same time as fentanyl itself and had only rarely been encountered on the illicit market in the late s. However, in , Canadian police seized 3 kilograms of acetylfentanyl. Common side effects of fentanyl analogs are similar to those of fentanyl itself, which include itching , nausea and potentially serious respiratory depression , which can be life-threatening. Fentanyl analogs have killed hundreds of people throughout Europe and the former Soviet republics since the most recent resurgence in use began in Estonia in the early s, and novel derivatives continue to appear. Acetylfentanyl has been analytically confirmed in 32 fatalities in four European member states between and August , Germany 2 , Poland 1 , Sweden 27 and the United Kingdom 2. Twelve deaths have been associated with acetylfentanyl in Russia since The Centers for Disease Control and Prevention CDC issued a health alert to report that between March and May , 14 overdose deaths related to injected acetylfentanyl had occurred among intravenous drug users ages between 19 and 57 years in Rhode Island. After confirming five overdoses in one county, including a fatality, Pennsylvania asked coroners and medical examiners across the state to screen for acetylfentanyl. As a result of this investigation, Pennsylvania confirmed at least one acetylfentanyl overdose death and attributed at least 50 fatalities to either fentanyl or acetylfentanyl during the first half of As an analog of fentanyl, acetylfentanyl is a Schedule I controlled drug. As of October, acetylfentanyl is a controlled substance in China. Acetylfentanyl is a Schedule I controlled substance as of May Acetylfentanyl is illegal in Switzerland as of December Acetylfentanyl was made a class A drug as an analogue of fentanyl in Acetylfentanyl overdosage has been reported to closely resemble heroin overdosage clinically. Additionally, while naloxone Narcan is effective in treating acetylfentanyl overdose, larger than normal doses of the antidote may be required. Acetylfentanyl may be quantitated in blood, plasma or urine by liquid chromatography-mass spectrometry to confirm a diagnosis of poisoning in hospitalized patients or to provide evidence in a medicolegal death investigation. From Wikipedia, the free encyclopedia. Schedule I \\\\\\\\\\\\\\\\\[1\\\\\\\\\\\\\\\\\] DE: District of Rhode Island. US Department of Justice. Structure-analgesic activity relationship for fentanyl, methyl-substituted fentanyls and other analogues'. Are we missing the signs? Highly potent and on the rise in Europe'. International Journal of Drug Policy. Journal of Analytical Toxicology. Journal of Analytical Chemistry. Morbidity and Mortality Weekly Report. Journal of Medical Toxicology. China Food and Drug Administration. Retrieved 1 October Retrieved 30 June Disposition of toxic drugs and chemicals in man PDF. Analgesics N02A , N02B. Meclofenamic acid Mefenamic acid. Cannabidiol Cannabis Nabilone Nabiximols Tetrahydrocannabinol dronabinol. Gabapentin Gabapentin enacarbil Pregabalin Ziconotide. Carbamazepine Lacosamide Local anesthetics e. Agonists abridged; see here for a full list: Retrieved from ' https: Views Read Edit View history. This page was last edited on 21 June , at By using this site, you agree to the Terms of Use and Privacy Policy. Calcium blockers Gabapentin Gabapentin enacarbil Pregabalin Ziconotide.

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