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It was developed in as a medication for Soviet Cosmonauts to treat the prolonged stresses of working in space. Research on animals has indicated that phenylpiracetam may have anti-amnesic , antidepressant , anticonvulsant , anxiolytic , and memory enhancement effects. A few small clinical studies have shown possible links between prescription of phenylpiracetam and improvement in a number of encephalopathic conditions, including lesions of cerebral blood pathways, traumatic brain injury and certain types of glioma. Phenylpiracetam reverses the depressant effects of the benzodiazepine diazepam , increases operant behavior , inhibits post-rotational nystagmus , prevents retrograde amnesia , and has anticonvulsant properties. Phenylpiracetam is typically prescribed as a general stimulant or to increase tolerance to extreme temperatures and stress. The Serbsky Center , Moscow Institute of Psychiatry, and Russian Center of Vegetative Pathology are reported to have confirmed the effectiveness of Phenylpiracetam Phenytropil describing the following effects: In Wistar rats with gravitational cerebral ischemia , Phenylpiracetam reduced the extent of neuralgic deficiency manifestations, retained the locomotor, research, and memory functions, increased the survival rate, and lead to the favoring of local cerebral flow restoration upon the occlusion of carotid arteries to a greater extent than did piracetam. Phenylpiracetam is known to increase operant behavior. In tests against a control , Sprague-Dawley rats given free access to less-preferred rat chow and trained to operate a lever repeatedly to obtain preferred rat chow performed additional work when given methylphenidate , d-amphetamine , and phenylpiracetam. Present data show that R -phenylpiracetam increases motivation, i. At the same time consumption of freely available normal food does not increase. Generally this indicates that R -phenylpiracetam increase motivation \\\\\\\\\\\\\[ In rats , scopolamine is used to model memory impairment. It impairs performance in the conditioned passive avoidance reflex test, increases cortical nACh and hippocampal NMDA receptor densities, and decreases striatal D 1 and cortical benzodiazepine receptor densities. Phenylpiracetam demonstrates antiamnestic activity by restoring performance in the passive avoidance test and partially reversing each of these scopolamine-induced receptor density changes. Experiments performed on Sprague-Dawley rats in a European patent for using Phenylpiracetam to treat sleep disorders showed an increase in extracellular dopamine levels after administration. The peculiarity of this invention compared to former treatment approaches for treating sleep disorders is the so far unknown therapeutic efficacy of R -phenylpiracetam, which is presumably based at least in part on the newly identified activity of R -phenylpiracetam as the dopamine re-uptake inhibitor. Phenylpiracetam may also act as a noradrenaline reuptake inhibitor , making it an NDRI. While not prescribed as a pharmaceutical in the West , in Russia it was available as a prescription medicine under the name Phenotropil until April Phenylpiracetam is not scheduled by the DEA in the U. Phenylpiracetam is readily-synthesized commercially. To avoid the problem of attaching the phenyl group to piracetam at position 5 rather than 3 or 4, commercial syntheses cyclizes phenibut by replacing the hydroxide with a hydrogen to create a pyrrole group and then reacting bromoacetic acid and ammonia to replace the bromine with the nitrogen on the pyrrole. This produces a racemic phenylpiracetam, which then undergoes purification to produce the final product. Because it increases physical stamina and provides improved tolerance to cold weather, \\\\\\\\\\\\\[ medical citation needed \\\\\\\\\\\\\] it appears on the lists of stimulants banned for in-competition use by the World Anti-Doping Agency. This list is applicable in all Olympic sports. From Wikipedia, the free encyclopedia. This article has multiple issues. Please help improve it or discuss these issues on the talk page. Learn how and when to remove these template messages. The specific problem is: This is original research unless reliable sources making those connections can be produced. The article suggests that there are benefits for healthy individuals, but the only clinical study referenced relates to brain damaged subjects. Please help improve this article if you can. September Learn how and when to remove this template message. This article needs more medical references for verification or relies too heavily on primary sources. Please review the contents of the article and add the appropriate references if you can. Unsourced or poorly sourced material may be challenged and removed. Retrieved 31 December Zhurnal nevrologii i psikhiatrii imeni S. Adapromine Amantadine Bromantane Memantine Rimantadine. Oxiracetam Phenylpiracetam Phenylpiracetam hydrazide. Retrieved from ' https: Views Read Edit View history. This page was last edited on 8 September , at By using this site, you agree to the Terms of Use and Privacy Policy.
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