2 cb

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It was first synthesized by Alexander Shulgin in It first saw use among the psychiatric community as an aid during therapy. It was considered one of the best drugs for this purpose because of its short duration, relative absence of side effects, and comparably mild nature. The September Journal of Analytical Toxicology reported that very little data exists about the pharmacological properties, metabolism, and toxicity of 2C-B. The relationship between its use and death are unknown. The lethal dosage is unknown. The authors suggested that this compound was a by-product of 2C-B synthesis. Little or no academic research has been conducted on the effects of 2C-B in humans. The information available is largely anecdotal and limited. Effects are often described as being more easily managed than other psychedelics; \\\\\\\\\\\\\\\[13\\\\\\\\\\\\\\\] it is often compared to a mixture of a serotonergic psychedelic and MDMA. The anecdotal effects of 2C-B that have been reported by users on online discusion forums include: When orally consumed, 2C-B has a much longer delay before the onset of effects than when it is insufflated. Oral ingestion generally takes roughly 45—75 minutes for the effects to be felt, plateau lasts 2—4 hours, and coming down lasts 1—2 hours. Rectal administration 'boofing' onset varies from 5—20 minutes. Insufflated onset takes 1—10 minutes for effects to be felt. The duration can last from 4 to 12 hours depending on ROA, dose, and other factors. With insufflation the effects are more abrupt and intense but have a significantly shorter duration, while oral usage results in a milder, longer experience. When insufflated, the onset happens very rapidly, usually reaching the peak at about 20—40 minutes and plateauing for 2—3 hours. Unlike most hallucinogens, 2C-B has been shown to be a low efficacy serotonin 5-HT 2A receptor partial agonist or even full antagonist. Research suggests that 2C-B increases dopamine levels in the brains of rats, which may contribute to its psychoactivity. Alternatively, the later metabolites can be generated by demethylation of 2C-B followed by oxidative deamination. There is species differentiation in the metabolism of 2C-B. Mice hepatocytes produce 4-bromo-2,5-dimethoxy-phenol BDMP a previously unknown metabolite. Analogues and derivatives of 2C-B:. The N-benzyl derivative however was found to have higher binding affinity than 2C-B itself, with N- 4-bromobenzyl -2CB binding even more tightly again. It was placed on Schedule One of the Drugs Misuse and Trafficking Act when it first came to notice in , when in a showcase legal battle chemist R. Simpson was charged with manufacturing the substance in Sydney NSW. Alexander Shulgin came to Australia to testify on behalf of the defense to no avail. In Brazil, 2C-B is a controlled substance making production, distribution, and possession illegal. In Belgium, 2C-B is a controlled substance making production, distribution, and possession illegal. This is to include the other 2C-x analogues. Possession of more than mg of 2C-B is punishable with a two years jail sentence. In Denmark, 2C-B is listed as a category B drug. However, this was corrected in a new document, LVFS All drugs in the 2C family are Class A under the Misuse of Drugs Act which means they are illegal to produce, supply or possess. Possession carries a maximum sentence of seven years imprisonment while supply is punishable by life imprisonment and an unlimited fine. From Wikipedia, the free encyclopedia. Anlage I Authorized scientific use only UK: This section needs more medical references for verification or relies too heavily on primary sources. Please review the contents of the section and add the appropriate references if you can. Unsourced or poorly sourced material may be challenged and removed. Analogues and derivatives of 2C-B: Archived from the original PDF on October 16, National Drug Intelligence Center. Retrieved 11 February Retrieved 25 September Retrieved May 15, Journal of Analytical Toxicology. Retrieved 16 August Presence in the recreational drug market in Spain, pattern of use and subjective effects'. Analysis of phase I metabolism with hepatocytes of six species including human'. The Journal of Pharmacology and Experimental Therapeutics. Journal of Medicinal Chemistry. Entwicklung eines neuen Struktur-Wirkungskonzepts \\\\\\\\\\\\\\\[ Synthesis and pharmacology of potent 5-HT 2A receptor agonists which have a partial Nmethoxybenzyl structure: Development of a new structure-activity concept \\\\\\\\\\\\\\\] Thesis in German. Free University of Berlin. Retrieved August 1, Archived from the original PDF on 2 March Archived from the original on Swiss Agency for Therapeutic Products. Diphenidine Ephenidine Fluorolintane Methoxphenidine. Dextrallorphan Dextromethorphan Dextrorphan Racemethorphan Racemorphan. Apomorphine Aporphine Bromocriptine Cabergoline Lisuride Memantine Nuciferine Pergolide Phenethylamine Piribedil Pramipexole Ropinirole Rotigotine Salvinorin A Also indirect D 2 agonists, such as dopamine reuptake inhibitors cocaine , methylphenidate , releasing agents amphetamine , methamphetamine , and precursors levodopa. Glaucine Isoaminile Noscapine Pukateine. AR-A Beta blockers e. Agomelatine Atypical antipsychotics e. Adatanserin Agomelatine Atypical antipsychotics e. Alosetron AS Atypical antipsychotics e. ABT Atypical antipsychotics e. Retrieved from ' https: Views Read Edit View history. This page was last edited on 22 October , at By using this site, you agree to the Terms of Use and Privacy Policy.

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2C-B – психоделик нового типа, последствия

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