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Child mystery in the Kingdom has led to the discovery of a deadly genetic defect | BT Society - www.bt.dk Something miraculous has happened at Rigshospitalet in Copenhagen. For several weeks, chief physicians, doctors and nurses have been bewildered by a mystery. They simply could not find out why a 22-month-old Greenlandic child was so seriously ill. Aarhus University writes in a press release. The child showed severe signs of meningitis and tuberculosis, but no treatment worked as intended and the child's condition became more and more severe. And one had to seek outside help. Therefore, in March 2021, Professor Trine Hyrup Mogensen and her research group at the Department of Biomedicine at Aarhus University were contacted. The analysis of the child's genetic genome was surprising. The researchers discovered a defect in a gene called IFNAR2. A genetic defect in peoples of Inuit descent in Greenland, Canada and Alaska. "At first we did not think it meant anything, because it is a new mutation that does not appear in databases as pathogenic," explains Trine Mogensen. Trine Hyrup Mogensen The researchers performed analyzes of the patient's cells. It quickly became clear that the patient's cells were not at all able to resist and make an antiviral response. The cells could not form a signaling molecule that is normally released by cells during viral infections to mobilize the body's defense mechanisms. In the patient cells, there was uncontrolled virus production and the cells simply died. Trine Hyrup Mogensen's group came into contact with some British researchers who focused on children from Alaska and Canada. The children died or became very ill after covid infection, influenza or two to three weeks after the MMR vaccine. It is very unusual, said Trine Hyrup Mogensen. It turns out that 1 in 1,500 has inherited the genetic defect from both parents and thus is extremely vulnerable to viral infections and vaccines with live viruses such as the MMR vaccine. »The discovery means that screenings should be used. At the same time, it is extremely important that no antivaccine reactions occur in the populations affected. In Greenland, 80 per cent receive the MMR vaccine, but the figure is only 40 per cent in the remote cities, «explains Trine Hyrup Mogensen, who is in contact with the medical superior in Greenland. Check it out here Media: The votes have been counted On bare bottom: ABROAD ABROAD Berlingske Media A / S Pilestræde 34 DK-1147 Copenhagen KTlf. +45 33 75 75 33 CVR.no .: 29 20 73 13